US residents only

US residents only

What to know about starting ZYMFENTRA

You may have questions about starting ZYMFENTRA™ and what to expect from treatment.

To learn more, choose the statement that best describes you:

I’m new to infliximab treatment

New to infliximab treatment?

How to START—and STAY—on treatment

One of the biggest things to know is that treatment involves 2 phases:

Start Phase

There is a starting period to your treatment journey where you will be given medicine at an infusion center or doctor’s office. The medicine you’ll receive is the same medicine as ZYMFENTRA, only given intravenously, which means it is delivered into a vein in your arm. You will receive this medicine 3 times over 6 weeks.

WHAT TO EXPECT:

A doctor or nurse will be there to check on you while the medicine is given.

You will be seated comfortably the whole time. The entire appointment may take several hours from the time you arrive to when you leave.

After your first appointment, you will return at Weeks 2 and 6 to receive your next 2 doses.

Start Phase (1)

Stay Phase

Four weeks after the last infusion appointment and under the guidance of a doctor, patients or their caregivers can SHIFT to injecting ZYMFENTRA themselves every 2 weeks from the comfort of home.

At home, store ZYMFENTRA in a refrigerator at 36°F to 46°F (2°C to 8°C). If needed, you may store ZYMFENTRA at room temperature at 68°F to 77°F (20°C to 25°C) for up to 14 days.

  • Once stored at room temperature, ZYMFENTRA should not be placed back into the refrigerator
  • Throw away (discard) if not used within the 14 days
  • Do not freeze or shake ZYMFENTRA
  • Be sure to keep ZYMFENTRA in the original carton until ready to use to protect it from light

ZYMFENTRA is a subcutaneous injection. This means it is injected just below the skin and not into a vein, so you can safely inject it yourself.

I’m already receiving maintenance treatment with IV infliximab

Already receiving maintenance treatment with IV infliximab?

How to SHIFT to treatment with ZYMFENTRA

There are 2 phases to treatment:

CURRENT Phase

If you are already responding well to ongoing treatment with infliximab given at an infusion center or doctor’s office, it is easy to make the shift to ZYMFENTRA.

Shift To Zymfentra

Stay Phase

After the last infusion appointment and under the guidance of a doctor, patients or their caregivers can SHIFT to injecting ZYMFENTRA themselves every 2 weeks from the comfort of home.

At home, store ZYMFENTRA in a refrigerator at 36°F to 46°F (2°C to 8°C). If needed, you may store ZYMFENTRA at room temperature at 68°F to 77°F (20°C to 25°C) for up to 14 days.

  • Once stored at room temperature, ZYMFENTRA should not be placed back into the refrigerator
  • Throw away (discard) if not used within the 14 days
  • Do not freeze or shake ZYMFENTRA
  • Be sure to keep ZYMFENTRA in the original carton until ready to use to protect it from light

ZYMFENTRA is a subcutaneous injection. This means it is injected just below the skin and not into a vein, so you can safely inject it yourself.

How to inject ZYMFENTRA

For more information about injecting ZYMFENTRA, refer to these materials found in your Patient Starter Kit

How To Use Guide

How to Use ZYMFENTRA Brochure

Get step-by-step instructions for how
to inject ZYMFENTRA.

Dosing Diary Copy

Dosing Diary

Keep track of your injection sites and dates
of injection with this handy diary.

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Still need help with injections?

Celltrion provides injection training support from registered nurses. 

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Do you already receive IV infliximab (Remicade®, Inflectra®, Renflexis®, or Avsola®)? Interested in injecting infliximab at home? Talk with your doctor about whether you should consider shifting to ZYMFENTRA.

REMICADE® (infliximab), INFLECTRA® (infliximab-dyyb), RENFLEXIS® (infliximab-abda), and AVSOLA® (infliximab-axxq) are registered trademarks of other companies.

Important Safety Information

ZYMFENTRA is a prescription medicine used as an injection under the skin (subcutaneous injection) by adults for the maintenance treatment of moderately to severely active ulcerative colitis or Crohn’s disease following treatment with an infliximab product given by intravenous infusion (IV).

What is the most important information I should know about ZYMFENTRA?

ZYMFENTRA may cause serious side effects, including risk of infection and cancer.

Do not take ZYMFENTRA if you:

Before you receive ZYMFENTRA, tell your doctor about all of your medical conditions, including if you:

What should I avoid while taking ZYMFENTRA?

What are the possible side effects of ZYMFENTRA?
ZYMFENTRA can cause serious side effects, including:

The most common side effects include COVID-19, joint pain, respiratory infections, such as sinus infections and sore throat, diarrhea, injection site reactions, high blood pressure, headache, urinary tract infections, abdominal pain, dizziness, abnormal liver enzymes.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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